April 18, 2016

Can Pediatric Neuro-Sarcoidosis cause pituitary Dwarfism (Hyposomatotropism) in children ?

Can Pediatric Neuro-Sarcoidosis cause pituitary Dwarfism (Hyposomatotropism) in children ?



More than 200 conditions are known to cause short stature in a child. Most of these are caused by a spontaneous genetic mutation in the egg or sperm cells prior to conception. Other conditions are caused by genes inherited from one or both parents. In either of these cases, two average-size parents can have a child with short stature (though this is far more likely to occur with a spontaneous mutation). Similarly, depending on the type of condition causing the short stature, it is possible for little people to have an average-size child.

What prompts a gene to mutate is not yet clearly understood. The change is seemingly random and unpreventable, and can occur in any pregnancy. Generally, when average-size parents have a child with short stature due to a spontaneous mutation, it is rare to have a second child who is also of short stature. However, if parents have some form of dwarfism themselves, the odds are much greater that their children will have it as well. A genetic counselor can help determine the likelihood of passing on the condition in these cases.

Dwarfism has other causes, including metabolic or hormonal disorders in infancy or childhood. Chromosomal abnormalities, pituitary gland disorders (which influence growth and metabolism), absorptive problems (when the body can’t absorb nutrients adequately), and kidney disease can all lead to short stature if a child fails to grow at a normal rate. http://kidshealth.org/parent/medical/bones/dwarfism.html
Causes of hypopituitarism can directly affect the pituitary gland or indirectly through the hypothalamus, which in turn affects the pituitary gland. Causes of hypopituitarism includes sarcoidosis – a rare inflammation of the lymph nodes and other tissues throughout the body. https://www.lancastergeneral.org/CONTENT/greystone_20664.asp

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